Problem Overview

Mycoplasmal pneumonia, Actinobacillus pleuropneumonia and Glasser disease are different infections, but they can occur in the same production system and may contribute to a broader porcine respiratory disease complex. Coughing, fever, reduced feed intake, labored breathing, uneven growth and sudden mortality can overlap, especially when viral pressure, mixing, poor ventilation or secondary bacteria are also present.

The three diseases should therefore be managed together at program level but not treated as if they were identical. Age, speed of onset, fever, mortality pattern, lung lesions, joint or nervous signs and laboratory results determine which pathogen is most important and how urgent the response must be.

This page presents Guanghua Biotechnology’s combined product solution of Florfenicol Injection plus Banlangen Crude Extract. Final use must follow local product registration, approved labels, withdrawal periods and veterinary guidance. Severe outbreaks require immediate veterinary assessment and should not wait for feed or water consumption to recover.

1. Differentiate the Three Diseases

Mycoplasmal pneumonia

Mycoplasma hyopneumoniae usually produces a chronic dry cough, reduced daily gain, poorer feed conversion and uneven finishing groups. Uncomplicated disease often has low mortality, but it damages respiratory defenses and increases the impact of other PRDC pathogens. A sudden high fever or rapidly rising mortality suggests that another infection is involved.

Actinobacillus pleuropneumonia

Actinobacillus pleuropneumoniae, often abbreviated APP, can progress within hours. High fever, refusal to move, severe breathing difficulty, open-mouth breathing, blood-stained froth and sudden death are important warning signs. Recovered pigs may remain carriers, so emergency treatment alone does not remove the herd-level source.

Glasser disease

Glaesserella parasuis, formerly called Haemophilus parasuis, can invade beyond the respiratory tract. Fever and breathing difficulty may occur together with swollen joints, lameness, meningitis, trembling or fibrinous inflammation around the heart, lungs and abdominal organs. Detection in a nasal swab alone is not enough because the organism may also colonize healthy pigs.

2. Diagnosis Before Treatment

Select untreated, clearly affected pigs for sampling whenever possible. For Mycoplasma, PCR and characteristic cranioventral lung lesions can support herd diagnosis. For APP, culture or PCR from fresh lung lesions and the typical hemorrhagic, necrotic pneumonia pattern are important. For Glasser disease, collect from systemic lesions such as pleura, pericardium, joints or brain rather than relying only on upper respiratory samples.

The differential list should also include PRRS, swine influenza, circovirus-associated disease, Pasteurella infection, Streptococcus suis and environmental pneumonia. Treatment history matters because antimicrobial use before sampling can reduce culture success.

Record the affected age, first signs, rectal temperature, morbidity, mortality, vaccination status, recent mixing, ventilation changes and previous response. This information helps separate chronic Mycoplasma pressure from an acute APP emergency or systemic Glasser disease.

3. Recommended Treatment Solution

Florfenicol Injection is the antibacterial component of this combined program. It is intended for susceptible bacterial respiratory pathogens when the product is approved for pigs and the farm veterinarian confirms that its use is appropriate. Injection can be valuable when severely affected animals are no longer consuming enough medicated feed or water.

Banlangen Crude Extract is used alongside florfenicol in Guanghua’s respiratory-support solution. It is positioned as complementary support during respiratory pressure and recovery, not as a substitute for antibacterial treatment, diagnosis, ventilation correction or biosecurity. Product specifications and market availability can be requested from our technical team.

In this program, Florfenicol Injection and Banlangen Crude Extract are used together as a coordinated solution rather than as two unrelated products. The exact dose, route, treatment duration and eligible animals must follow the registered labels in the destination market and the attending veterinarian’s protocol. Do not invent a dose from a web article or apply the same schedule across products with different concentrations.

The combination does not guarantee success in every respiratory outbreak. Delayed treatment, resistant bacteria, advanced lung damage, viral coinfection, poor ventilation and continued exposure to carrier pigs can all limit response. Farms should reassess the diagnosis when fever, breathing difficulty, mortality or feed intake does not improve within the veterinarian’s expected review period.

4. Supportive Management

Move severely affected pigs to a warm, dry recovery area with easy access to clean water. Reduce handling and transport stress. Check drinker flow, because dehydration and low consumption can undermine recovery even when the selected medicine is appropriate.

Correct ventilation without creating cold drafts at pig level. Ammonia, dust, excessive humidity and temperature swings damage airway defenses and increase coughing. Stocking density and mixing should be reviewed at the same time, particularly when disease appears after transfer or regrouping.

Nutritional support may help maintain recovery when appetite has fallen, but feed additives do not eradicate Mycoplasma, APP or Glaesserella. Keep treatment, nutritional support and environmental correction as separate parts of one measured program.

5. Herd-Level Prevention

Control introductions and carrier risk

Know the respiratory health status of replacement and feeder pigs, use quarantine and avoid mixing animals from incompatible sources. APP and Mycoplasma can persist in carrier populations, while unfamiliar Glaesserella strains may destabilize naive groups.

Use vaccination strategically

Vaccination can reduce clinical disease and lesions where suitable products are available, but it does not replace source-herd control or environment management. Glasser disease vaccine performance can depend on strain matching and herd context. Build vaccination timing around maternal immunity, challenge age and diagnostic evidence.

Strengthen pig flow and room hygiene

All-in/all-out flow, complete cleaning, drying time and avoiding back-mixing reduce carryover between batches. Review recurring disease by room and source instead of treating each affected pig as an isolated event.

6. Response Monitoring

Before treatment, record temperature, respiratory effort, cough frequency, feed intake, mortality and the number of newly affected pigs. Repeat the same observations at agreed intervals. A useful response should include fewer new cases, improved appetite, lower fever and easier breathing, not merely temporary quietness.

At batch level, compare average daily gain, feed conversion, mortality, treatment rate, slaughter pleurisy and lung-lesion scores. These measures show whether the program is reducing production loss and whether prevention changes are working in later groups.

If response is poor, review sampling, susceptibility, injection technique, product concentration, timing, coinfection and environmental pressure. Do not automatically add more antimicrobials without a revised diagnosis.

7. Application Suggestions and Precautions

Use Florfenicol Injection only for species, indications and routes permitted by the local label. Observe contraindications, maximum treatment limits, withdrawal periods and storage requirements. Maintain complete medicine records for every treated group.

Do not mix injectable products in the same syringe unless compatibility and the registered instructions explicitly allow it. Banlangen Crude Extract should be administered according to its own approved formulation and route. The phrase “combined solution” describes the farm program and does not imply physical mixing.

Open-mouth breathing, blood-stained froth, sudden deaths, neurological signs, widespread lameness or rapidly rising fever require urgent veterinary action. Suspected notifiable disease must follow local reporting rules.

FAQ

Are these three diseases the same?

No. They involve different pathogens and disease patterns, but they may overlap within PRDC and can be addressed within one diagnostic and management program.

Why combine Florfenicol Injection with Banlangen Crude Extract?

Florfenicol is the antibacterial component for susceptible bacterial disease, while Banlangen Crude Extract provides complementary support within Guanghua’s respiratory solution. Selection must follow diagnosis and local approval.

Can the combination replace laboratory diagnosis?

No. Similar signs can result from viral, bacterial, environmental or mixed causes, and the correct samples help prevent repeated ineffective treatment.

Can products be mixed in one syringe?

Not unless the registered instructions specifically confirm compatibility. Treat the products as coordinated parts of a program, not automatically as a physical mixture.

When should the farm contact a veterinarian immediately?

Immediately when pigs show severe breathing difficulty, blood-stained froth, sudden death, neurological signs, high fever or rapidly increasing case numbers.

References

MSD Veterinary Manual, Mycoplasmal Pneumonia in Pigs.

MSD Veterinary Manual, Pleuropneumonia in Pigs.

MSD Veterinary Manual, Glasser Disease in Pigs.

World Organisation for Animal Health, Responsible and Prudent Use of Antimicrobial Agents in Veterinary Medicine.